Partial explanation of the mechanism of corona sequelae
This is an epoch-making achievement in research on the long post-acute COVID-19 sequelae of the new corona. When Professor Ueno of Kyoto University analyzed the blood of patients with a strong sense of malaise, it was found that there are many immune cells that eliminate the virus and suppress its function. It is thought that the simultaneous increase of two cells leads to malaise due to the inability to regulate immunity.
Professor Hideki Ueno of Kyoto University analyzed immune cells called "T cells" from the blood of patients with sequelae of the new corona.
When a virus invades the body, it infects cells.
There are multiple types of "T cells", which play a role in eliminating virus-infected cells and suppressing immune runaway.
Studies have shown that patients with severe malaise produce more cells that have the ability to eliminate the virus and cells that suppress it than those with mild symptoms.
Professor Hideki Ueno, Kyoto University: "Without these cells, virus elimination is not progressing easily, but there is a possibility that these patients are a little too strong. Immune people are trying to suppress it, but I say by car. I think I haven't been able to regulate the body's immune response well when I'm stepping on the brakes with the accelerator. ”
Also, for patients with only olfactory and taste disorders, there are extremely few cells that eliminate the virus. I also understood that.
Professor Ueno believes that when infected, not many cells were created to eliminate the virus, so even after recovery, virus fragments remain in the body and cause symptoms.
Now that we have learned a part of the mechanism of sequelae, it is expected that it will be useful for diagnosis and treatment in the future.
Professor Hideki Ueno, Kyoto University: "I don't have a solid diagnosis, I can't find a treatment. I think there is a current situation where I don't know where to go, so after clarifying that there is such an immune disorder, I hope it will help in the diagnosis. I think that what we basic immunologists can do is to provide solid evidence. Find new things using samples obtained from patients with clinical symptoms. I think that will lead to diagnosis and treatment. ”
Professor Ueno will continue to study patients with aftereffects and publish a paper summarizing the results.
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